Issue 52, 2012

Efficient catalytic cyclizations of three and two imine assemblies: direct access to tetrahydroimidazo[1,5-c]imidazol-7-ones and imidazoles

Abstract

A cascade cyclization involving union of three imines by an organocatalyst proline is established to afford new fused-tetrahydroimidazo[1,5-c]imidazol-7-ones with excellent regio- and stereoselectivity. Another dehydrogenative cyclization by union of two imines is developed using the Cu(OTf)2–Ag2O combo catalyst to furnish functionalized imidazoles.

Graphical abstract: Efficient catalytic cyclizations of three and two imine assemblies: direct access to tetrahydroimidazo[1,5-c]imidazol-7-ones and imidazoles

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2012
Accepted
01 May 2012
First published
24 May 2012

Chem. Commun., 2012,48, 6601-6603

Efficient catalytic cyclizations of three and two imine assemblies: direct access to tetrahydroimidazo[1,5-c]imidazol-7-ones and imidazoles

Y. Saima, S. Khamarui, K. S. Gayen, P. Pandit and D. K. Maiti, Chem. Commun., 2012, 48, 6601 DOI: 10.1039/C2CC32760K

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