α/γ4-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix

Anupam Bandyopadhyay; Sandip V. Jadhav; Hosahudya N. Gopi

doi:10.1039/C2CC32911E

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α/γ⁴-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix†

Anupam Bandyopadhyay,^a Sandip V. Jadhav^a and Hosahudya N. Gopi*^a

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* Corresponding authors

^a Department of Chemistry, Indian Institute of Science Education and Research, Dr Homi Bhabha Road, Pashan, Pune-411021, India
E-mail: hn.gopi@iiserpune.ac.in
Fax: +91-20-2589-9790
Tel: +91-20-2590-8075

Abstract

Synthesis, crystal conformations of α/γ⁴-hybrid peptide helices containing proteinogenic amino acid side-chains, and the analogy with the α-helix are reported. Results suggest that α/γ⁴-hybrid peptides adopted helical conformations with 12-membered H-bond pseudocycles in single crystals.

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Article information

DOI: https://doi.org/10.1039/C2CC32911E
Article type: Communication
Submitted: 24 Apr 2012
Accepted: 27 May 2012
First published: 29 May 2012

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Chem. Commun., 2012,48, 7170-7172

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α/γ⁴-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix

A. Bandyopadhyay, S. V. Jadhav and H. N. Gopi, Chem. Commun., 2012, 48, 7170 DOI: 10.1039/C2CC32911E

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