Issue 58, 2012
From the journal:

Chemical Communications

Efficient synthesis of optically active α-quaternary amino acids by highly diastereoselective [2,3]-rearrangement of allylic ammonium ylides†

Ting-Shun Zhua  and  Ming-Hua Xu*a  

* Corresponding authors

a State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China
E-mail: xumh@mail.shcnc.ac.cn
Fax: +86 21 5080 7388
Tel: +86 21 5080 7388

Abstract

A pincer-like chiral auxiliary strategy for synthesizing various optically active α,α-disubstituted amino acids in high yields with excellent enantioselectivities is described.

Graphical abstract: Efficient synthesis of optically active α-quaternary amino acids by highly diastereoselective [2,3]-rearrangement of allylic ammonium ylides

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Article information

DOI
https://doi.org/10.1039/C2CC33027J
Article type
Communication
Submitted
27 Apr 2012
Accepted
17 May 2012
First published
25 May 2012

Chem. Commun., 2012,48, 7274-7276

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Efficient synthesis of optically active α-quaternary amino acids by highly diastereoselective [2,3]-rearrangement of allylic ammonium ylides

T. Zhu and M. Xu, Chem. Commun., 2012, 48, 7274 DOI: 10.1039/C2CC33027J

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