Issue 64, 2012
From the journal:

Chemical Communications

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids†

Jingchao Feng,a   Wenjin Yan,a   Dong Wang,a   Peng Li,a   Quantao Suna  and  Rui Wang*a  

* Corresponding authors

a Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, China
E-mail: wangrui@lzu.edu.cn

Abstract

The first asymmetric aza-Friedel–Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields.

Graphical abstract: The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

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Article information

DOI
https://doi.org/10.1039/C2CC33200K
Article type
Communication
Submitted
04 May 2012
Accepted
21 Jun 2012
First published
21 Jun 2012

Chem. Commun., 2012,48, 8003-8005

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The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

J. Feng, W. Yan, D. Wang, P. Li, Q. Sun and R. Wang, Chem. Commun., 2012, 48, 8003 DOI: 10.1039/C2CC33200K

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