Issue 63, 2012

Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Abstract

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

Graphical abstract: Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2012
Accepted
24 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 7790-7792

Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

B. Hong, P. Chen, P. Kotame, P. Lu, G. Lee and J. Liao, Chem. Commun., 2012, 48, 7790 DOI: 10.1039/C2CC33309K

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