Issue 86, 2012
From the journal:

Chemical Communications

A new strategy for effective construction of protein stacks by using cucurbit[8]uril as a glue molecule†

Haowei Yang,‡a   Qi An,‡b   Wei Zhu,a   Weina Li,a   Yin Jiang,a   Jiecheng Cui,a   Xi Zhanga  and  Guangtao Li*a  

* Corresponding authors

a Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, 100084 Beijing, China
E-mail: lgt@mail.tsinghua.edu.cn
Tel: +86-10-62792905

b School of Materials Science and Technology, China University of Geosciences, 100083 Beijing, China

Abstract

Cucurbit[8]uril (CB[8]) is found to induce the aggregation of pristine proteins in aqueous solution. Based on this finding, a new strategy for effective construction of layer-by-layer homo- and hetero-protein stacks was developed, where their bioactivities are preserved.

Graphical abstract: A new strategy for effective construction of protein stacks by using cucurbit[8]uril as a glue molecule

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Article information

DOI
https://doi.org/10.1039/C2CC33380E
Article type
Communication
Submitted
10 May 2012
Accepted
06 Sep 2012
First published
06 Sep 2012

Chem. Commun., 2012,48, 10633-10635

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A new strategy for effective construction of protein stacks by using cucurbit[8]uril as a glue molecule

H. Yang, Q. An, W. Zhu, W. Li, Y. Jiang, J. Cui, X. Zhang and G. Li, Chem. Commun., 2012, 48, 10633 DOI: 10.1039/C2CC33380E

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