Issue 61, 2012
From the journal:

Chemical Communications

A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones†

Pei Chui Tooa  and  Shunsuke Chiba*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: shunsuke@ntu.edu.sg
Fax: +65-67911961

Abstract

A method for synthesis of 4-bromoisoquinolones has been developed starting from 2-alkynylbenzaldehydes and primary amines mediated by CuBr under an O2 atmosphere, where CuBr plays multiple roles to facilitate the present reactions.

Graphical abstract: A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones

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Article information

DOI
https://doi.org/10.1039/C2CC33426G
Article type
Communication
Submitted
11 May 2012
Accepted
09 Jun 2012
First published
13 Jun 2012

Chem. Commun., 2012,48, 7634-7636

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A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones

P. C. Too and S. Chiba, Chem. Commun., 2012, 48, 7634 DOI: 10.1039/C2CC33426G

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