Issue 67, 2012
From the journal:

Chemical Communications

Gold nanoparticle based dot-blot immunoassay for sensitively detecting Alzheimer's disease related β-amyloid peptide†

Chengke Wang,ab   Dianjun Liua  and  Zhenxin Wang*a  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
E-mail: wangzx@ciac.jl.cn
Tel: +86 431 85262243

b Graduate School of the Chinese Academy of Sciences, Beijing, China

Abstract

A simple, sensitive gold nanoparticle (GNP)-based dot-blot immunoassay has been developed for detecting Alzheimer's disease related β-amyloid peptide 1–42 (Aβ1–42) down to a 50 pg mL−1 level in aqueous solution. Practical samples (cerebrospinal fluid (CSF), cell culturing mediums and cell lysates) have been used to demonstrate the ability of the assay.

Graphical abstract: Gold nanoparticle based dot-blot immunoassay for sensitively detecting Alzheimer's disease related β-amyloid peptide

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Article information

DOI
https://doi.org/10.1039/C2CC33568A
Article type
Communication
Submitted
17 May 2012
Accepted
02 Jul 2012
First published
16 Jul 2012

Chem. Commun., 2012,48, 8392-8394

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Gold nanoparticle based dot-blot immunoassay for sensitively detecting Alzheimer's disease related β-amyloid peptide

C. Wang, D. Liu and Z. Wang, Chem. Commun., 2012, 48, 8392 DOI: 10.1039/C2CC33568A

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