Issue 62, 2012
From the journal:

Chemical Communications

Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation†

Samya Banerjee,a   Puja Prasad,a   Akhtar Hussain,a   Imran Khan,b   Paturu Kondaiah*b  and  Akhil R. Chakravarty*a  

* Corresponding authors

a Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India
E-mail: arc@ipc.iisc.ernet.in
Tel: +91-80-22932533

b Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
E-mail: paturu@mrdg.iisc.ernet.in
Tel: +91-80-22933259

Abstract

Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400–700 nm giving IC50 = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC50 = 3.3 ± 0.4 μM), while both are less toxic in the dark.

Graphical abstract: Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation

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Article information

DOI
https://doi.org/10.1039/C2CC33576J
Article type
Communication
Submitted
17 May 2012
Accepted
07 Jun 2012
First published
29 Jun 2012

Chem. Commun., 2012,48, 7702-7704

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Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation

S. Banerjee, P. Prasad, A. Hussain, I. Khan, P. Kondaiah and A. R. Chakravarty, Chem. Commun., 2012, 48, 7702 DOI: 10.1039/C2CC33576J

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