Issue 65, 2012
From the journal:

Chemical Communications

Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides†

Zhichao Xiong,‡ab   Liang Zhao,‡a   Fangjun Wang,a   Jun Zhu,a   Hongqiang Qin,a   Ren'an Wu,a   Weibing Zhang*ab  and  Hanfa Zou*a  

* Corresponding authors

a CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China
E-mail: hanfazou@dicp.ac.cn

b Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 20023, China
E-mail: weibingzhang@ecust.edu.cn

Abstract

Hybrid Fe3O4@SiO2@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with high specifity, high sensitivity, and large binding capacity.

Graphical abstract: Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

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Article information

DOI
https://doi.org/10.1039/C2CC33600F
Article type
Communication
Submitted
18 May 2012
Accepted
15 Jun 2012
First published
25 Jun 2012

Chem. Commun., 2012,48, 8138-8140

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Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

Z. Xiong, L. Zhao, F. Wang, J. Zhu, H. Qin, R. Wu, W. Zhang and H. Zou, Chem. Commun., 2012, 48, 8138 DOI: 10.1039/C2CC33600F

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