Issue 64, 2012
From the journal:

Chemical Communications

Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds†

Mark W. Grafton,a   Louis J. Farrugia,a   Hans Martin Senna  and  Andrew Sutherland*a  

* Corresponding authors

a WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
E-mail: Andrew.Sutherland@glasgow.ac.uk
Fax: +44 141 330 4888
Tel: +44 141 330 5936

Abstract

A one-pot tandem process involving an Overman rearrangement, ring closing enyne metathesis and a hydrogen bonding directed Diels–Alder reaction has been developed for the efficient diastereoselective synthesis of functionalised amino substituted tetralin and indene ring systems.

Graphical abstract: Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds

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Article information

DOI
https://doi.org/10.1039/C2CC33649A
Article type
Communication
Submitted
21 May 2012
Accepted
18 Jun 2012
First published
19 Jun 2012

Chem. Commun., 2012,48, 7994-7996

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Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds

M. W. Grafton, L. J. Farrugia, H. M. Senn and A. Sutherland, Chem. Commun., 2012, 48, 7994 DOI: 10.1039/C2CC33649A

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