Issue 65, 2012
From the journal:

Chemical Communications

Enantioselective synthesis of levomilnacipran†‡

Julien Alliot,a   Edmond Gravel,a   Florence Pillon,a   David-Alexandre Buisson,a   Marc Nicolasb  and  Eric Doris*a  

* Corresponding authors

a CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France
E-mail: eric.doris@cea.fr
Fax: +33 169 08 79 91
Tel: +33 169 08 80 71

b Les Laboratoires Pierre Fabre, Centre de Développement de Chimie Industrielle, 16 rue Jean Rostand, 81600 Gaillac, France

Abstract

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

Graphical abstract: Enantioselective synthesis of levomilnacipran

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Article information

DOI
https://doi.org/10.1039/C2CC33743F
Article type
Communication
Submitted
24 May 2012
Accepted
22 Jun 2012
First published
22 Jun 2012

Chem. Commun., 2012,48, 8111-8113

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Enantioselective synthesis of levomilnacipran

J. Alliot, E. Gravel, F. Pillon, D. Buisson, M. Nicolas and E. Doris, Chem. Commun., 2012, 48, 8111 DOI: 10.1039/C2CC33743F

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