Issue 65, 2012

Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolinesviaamide activation

Abstract

A novel and general procedure for Cu-catalyzed coupling of enamides with alkynes to synthesize substituted pyridines was developed. The chemistry was allowed to extend to the synthesis of substituted isoquinolines by coupling of enamides with arynes under transition-metal-free conditions.

Graphical abstract: Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation

Supplementary files

Article information

Article type
Communication
Submitted
25 May 2012
Accepted
26 Jun 2012
First published
27 Jun 2012

Chem. Commun., 2012,48, 8105-8107

Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation

M. Zhao, Z. Ren, Y. Wang and Z. Guan, Chem. Commun., 2012, 48, 8105 DOI: 10.1039/C2CC33768A

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