Issue 67, 2012
From the journal:

Chemical Communications

Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy†

Nikolitsa Nomikou,a   Colin Fowley,b   Niall M. Byrne,b   Bridgeen McCaughan,b   Anthony P. McHale*b  and  John F. Callan*b  

* Corresponding authors

a Sonidel Ltd., Dublin 5, Republic of Ireland

b Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland
E-mail: j.callan@ulster.ac.uk, ap.mchale@ulster.ac.uk

Abstract

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

Graphical abstract: Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C2CC33913G
Article type
Communication
Submitted
31 May 2012
Accepted
20 Jun 2012
First published
21 Jun 2012

Chem. Commun., 2012,48, 8332-8334

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Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy

N. Nomikou, C. Fowley, N. M. Byrne, B. McCaughan, A. P. McHale and J. F. Callan, Chem. Commun., 2012, 48, 8332 DOI: 10.1039/C2CC33913G

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