Issue 75, 2012
From the journal:

Chemical Communications

Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction†

Shintaro Kawamura,ab   Tatsuya Kawabata,ab   Kentaro Ishizukaa  and  Masaharu Nakamura*ab  

* Corresponding authors

a International Research Center for Elements Science (IRCELS), Institute for Chemical Research, Kyoto University, Uji, Japan
E-mail: masaharu@scl.kyoto-u.ac.jp
Fax: +81-774-38-3186
Tel: +81-774-38-3180

b Department of Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Uji, Japan

Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction.

Graphical abstract: Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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Article information

DOI
https://doi.org/10.1039/C2CC34185A
Article type
Communication
Submitted
11 Jun 2012
Accepted
23 Jul 2012
First published
24 Jul 2012

Chem. Commun., 2012,48, 9376-9378

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Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

S. Kawamura, T. Kawabata, K. Ishizuka and M. Nakamura, Chem. Commun., 2012, 48, 9376 DOI: 10.1039/C2CC34185A

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