Issue 72, 2012
From the journal:

Chemical Communications

Total synthesis of ascididemin via anionic cascade ring closure†

Ida Nymann Petersen,‡a   François Crestey‡a  and  Jesper Langgaard Kristensen*a  

* Corresponding authors

a Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
E-mail: jekr@farma.ku.dk
Fax: +45 3533 6041
Tel: +45 3533 6487

Abstract

A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2′-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

Graphical abstract: Total synthesis of ascididemin via anionic cascade ring closure

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Article information

DOI
https://doi.org/10.1039/C2CC34725C
Article type
Communication
Submitted
02 Jul 2012
Accepted
20 Jul 2012
First published
23 Jul 2012

Chem. Commun., 2012,48, 9092-9094

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Total synthesis of ascididemin via anionic cascade ring closure

I. N. Petersen, F. Crestey and J. L. Kristensen, Chem. Commun., 2012, 48, 9092 DOI: 10.1039/C2CC34725C

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