Issue 72, 2012
From the journal:

Chemical Communications

Semisynthetic peptide–lipase conjugates for improved biotransformations†

Oscar Romero,a   Marco Filice,a   Blanca de las Rivas,b   Cesar Carrasco-Lopez,c   Javier Klett,d   Antonio Morreale,d   Juan A. Hermoso,c   Jose M. Guisan,a   Olga Abiane  and  Jose M. Palomo*a  

* Corresponding authors

a Departamento de Biocatálisis, Instituto de Catálisis (CSIC), Marie Curie 2. Cantoblanco. CampusUAM, 28049 Madrid, Spain
E-mail: josempalomo@icp.csic.es
Fax: +34 915854760

b Departamento de Biotecnología Microbiana, Instituto de Ciencia y Tecnología de alimentos y Nutrición, (ICTAN-CSIC), Madrid, Spain

c Departamento de Cristalografía y Biología Estructural, Instituto de Química-Física Rocasolano (CSIC), Madrid, Spain

d Unidad de Bioinformática, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

e Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, Zaragoza, Spain

Abstract

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

Graphical abstract: Semisynthetic peptide–lipase conjugates for improved biotransformations

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Article information

DOI
https://doi.org/10.1039/C2CC34816K
Article type
Communication
Submitted
05 Jul 2012
Accepted
23 Jul 2012
First published
24 Jul 2012

Chem. Commun., 2012,48, 9053-9055

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Semisynthetic peptide–lipase conjugates for improved biotransformations

O. Romero, M. Filice, B. D. L. Rivas, C. Carrasco-Lopez, J. Klett, A. Morreale, J. A. Hermoso, J. M. Guisan, O. Abian and J. M. Palomo, Chem. Commun., 2012, 48, 9053 DOI: 10.1039/C2CC34816K

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