Issue 74, 2012
From the journal:

Chemical Communications

Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkylGrignard reagents in the presence of 1,3-butadiene as an effective additive†

Ruwei Shen,a   Takanori Iwasaki,a   Jun Teraob  and  Nobuaki Kambe*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
E-mail: kambe@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7390
Tel: +81-6-6879-7390

b Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

Abstract

Cu-catalyzed cross-coupling of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as a ligand precursor was developed. The use of 1,3-butadiene resulted in improved yields of alkyl–alkyl products with improved selectivities.

Graphical abstract: Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as an effective additive

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Article information

DOI
https://doi.org/10.1039/C2CC34847K
Article type
Communication
Submitted
07 Jul 2012
Accepted
25 Jul 2012
First published
13 Aug 2012

Chem. Commun., 2012,48, 9313-9315

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Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as an effective additive

R. Shen, T. Iwasaki, J. Terao and N. Kambe, Chem. Commun., 2012, 48, 9313 DOI: 10.1039/C2CC34847K

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