Issue 74, 2012
From the journal:

Chemical Communications

Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA†

Zhimou Yang,a   Yi Kuang,b   Xinming Li,b   Ning Zhou,b   Ye Zhangb  and  Bing Xu*b  

* Corresponding authors

a Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, P. R. China

b Department of Chemistry, Brandeis University, 415 South St., Waltham, USA
E-mail: bxu@brandeis.edu
Fax: +1-781-736-5201

Abstract

As the first example of hydrogelator derived from aminoglycoside antibiotics, the hydrogel of kanamycin indicates that the hydrogel of aminoglycosides preserve the specific interaction with their macromolecular targets (e.g., 16S rRNA), thus illustrating a simple approach to explore and identify possible biological targets of supramolecular nanofibers/hydrogels.

Graphical abstract: Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA

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Article information

DOI
https://doi.org/10.1039/C2CC34935C
Article type
Communication
Submitted
10 Jul 2012
Accepted
26 Jul 2012
First published
26 Jul 2012

Chem. Commun., 2012,48, 9257-9259

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Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA

Z. Yang, Y. Kuang, X. Li, N. Zhou, Y. Zhang and B. Xu, Chem. Commun., 2012, 48, 9257 DOI: 10.1039/C2CC34935C

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