Issue 77, 2012
From the journal:

Chemical Communications

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy†

Jing-Xiang Zhang,‡*ab   Hongguang Li,‡a   Chi-Fai Chan,‡a   Rongfeng Lan,a   Wai-Lun Chan,a   Ga-Lai Law,*c   Wai-Kwok Wong*a  and  Ka-Leung Wong*a  

* Corresponding authors

a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, P. R. China
E-mail: klwong@hkbu.edu.hk, wkwong@hkbu.edu.hk
Fax: +852-3411-5862
Tel: +852-3411-7011

b Department of Chemistry, Hanshan Normal University, Chaozhou, Guangdong Province, P. R. China
E-mail: zhangjx_hk@hotmail.com

c Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Hum, Hong Kong SAR, P. R. China
E-mail: ga-lai.law@polyu.edu.hk

Abstract

An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

Graphical abstract: A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C2CC34963A
Article type
Communication
Submitted
11 Jul 2012
Accepted
09 Aug 2012
First published
09 Aug 2012

Chem. Commun., 2012,48, 9646-9648

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A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

J. Zhang, H. Li, C. Chan, R. Lan, W. Chan, G. Law, W. Wong and K. Wong, Chem. Commun., 2012, 48, 9646 DOI: 10.1039/C2CC34963A

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