Selective syntheses of no-carrier-added 2- and 3-[18F]fluorohalopyridines through the radiofluorination of halopyridinyl(4′-methoxyphenyl)iodonium tosylates

Joong-Hyun Chun; Victor W. Pike

doi:10.1039/C2CC35005J

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Selective syntheses of no-carrier-added 2- and 3-[¹⁸F]fluorohalopyridines through the radiofluorination of halopyridinyl(4′-methoxyphenyl)iodonium tosylates†

Joong-Hyun Chun^a and Victor W. Pike*^a

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* Corresponding authors

^a Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, USA
E-mail: pikev@mail.nih.gov
Fax: +1 301 480 5112
Tel: +1 301 594 5986

Abstract

No-carrier-added 2- and 3-[¹⁸F]fluorohalopyridines were readily synthesized as potentially useful labeling synthons for prospective PET radiotracers through the selective radiofluorination of halopyridinyl(4′-methoxyphenyl)iodonium tosylates, themselves conveniently prepared in a single pot from iodohalopyridines.

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Article information

DOI: https://doi.org/10.1039/C2CC35005J
Article type: Communication
Submitted: 12 Jul 2012
Accepted: 17 Aug 2012
First published: 20 Aug 2012

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Chem. Commun., 2012,48, 9921-9923

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Selective syntheses of no-carrier-added 2- and 3-[¹⁸F]fluorohalopyridines through the radiofluorination of halopyridinyl(4′-methoxyphenyl)iodonium tosylates

J. Chun and V. W. Pike, Chem. Commun., 2012, 48, 9921 DOI: 10.1039/C2CC35005J

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Chemical Communications