Issue 86, 2012
From the journal:

Chemical Communications

Raman spectroscopic detection of sub-picomolar DNA by coupling silver catalyzed silver deposition with circular strand-replacement polymerization on magnetic nanoparticles†

Fenglei Gao,a   Zhu Zhu,a   Jianping Leia  and  Huangxian Ju*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing 210093, P.R. China
E-mail: hxju@nju.edu.cn
Fax: +86 25 83593593
Tel: +86 25 83593593

Abstract

A novel strategy of dual signal amplification was developed using circular strand-replacement DNA polymerization with a molecular beacon as a switch and silver enhancement on magnetic nanoparticles for the specific Raman spectroscopic detection of DNA down to the sub-picomolar level.

Graphical abstract: Raman spectroscopic detection of sub-picomolar DNA by coupling silver catalyzed silver deposition with circular strand-replacement polymerization on magnetic nanoparticles

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Article information

DOI
https://doi.org/10.1039/C2CC35203F
Article type
Communication
Submitted
19 Jul 2012
Accepted
12 Aug 2012
First published
13 Aug 2012

Chem. Commun., 2012,48, 10603-10605

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Raman spectroscopic detection of sub-picomolar DNA by coupling silver catalyzed silver deposition with circular strand-replacement polymerization on magnetic nanoparticles

F. Gao, Z. Zhu, J. Lei and H. Ju, Chem. Commun., 2012, 48, 10603 DOI: 10.1039/C2CC35203F

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