Surface design of core–shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents

Dipak Maity; Giorgio Zoppellaro; Veronika Sedenkova; Jiri Tucek; Klara Safarova; Katerina Polakova; Katerina Tomankova; Clemens Diwoky; Rudolf Stollberger; Libor Machala; Radek Zboril

doi:10.1039/C2CC35515A

Surface design of core–shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents†

Dipak Maity,‡^a Giorgio Zoppellaro,*^a Veronika Sedenkova,^a Jiri Tucek,^a Klara Safarova,^a Katerina Polakova,^a Katerina Tomankova,^ab Clemens Diwoky,^c Rudolf Stollberger,^c Libor Machala^a and Radek Zboril*^a

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* Corresponding authors

^a Regional Centre of Advanced Technologies and Materials, Palacky University, 17. listopadu 12, 77146 Olomouc, Czech Republic
E-mail: giorgio.zoppellaro@upol.cz, radek.zboril@upol.cz
Fax: +420 58 563 4958
Tel: +420 58 563 497

^b Faculty of Medicine and Dentistry, Palacky University, 77146 Olomouc, Czech Republic

^c Graz University of Technology, Institute of Medical Engineering, A–8010 Graz, Austria

Abstract

Core–shell hydrophilic superparamagnetic iron oxide (SPIO) nanoparticles, surface functionalized with either terephthalic acid or 2-amino terephthalic acid, showed large negative MRI contrast ability, validating the advantage of using low molecular weight and π-conjugated canopies for engineering functional nanostructures with superior performances.

Chemical Communications

Surface design of core–shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents†

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Surface design of core–shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents

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