Issue 91, 2012

Iminium ion catalysis: the enantioselective Friedel–Crafts alkylation–acetalization cascade of naphthols with α,β-unsaturated cyclic ketones

Abstract

The first enantioselective Friedel–Crafts alkylation–acetalization-cascade of naphthols with α,β-unsaturated cyclic ketones and 1H-inden-1-ones was realized. 9-Amino(9-deoxy)epi-quinine A was the catalyst of choice for the realization of polycyclic structures with high enantiocontrol.

Graphical abstract: Iminium ion catalysis: the enantioselective Friedel–Crafts alkylation–acetalization cascade of naphthols with α,β-unsaturated cyclic ketones

Supplementary files

Article information

Article type
Communication
Submitted
01 Aug 2012
Accepted
04 Sep 2012
First published
04 Sep 2012

Chem. Commun., 2012,48, 11178-11180

Iminium ion catalysis: the enantioselective Friedel–Crafts alkylation–acetalization cascade of naphthols with α,β-unsaturated cyclic ketones

E. Paradisi, P. Righi, A. Mazzanti, S. Ranieri and G. Bencivenni, Chem. Commun., 2012, 48, 11178 DOI: 10.1039/C2CC35582E

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