Issue 91, 2012
From the journal:

Chemical Communications

Multifaceted folding in a foldamer featuring highly cooperative folds†

Veera V. E. Ramesh,a   Gowri Priya,a   Amol S. Kotmale,b   Rajesh G. Gonnade,c   Pattuparambil R. Rajamohananb  and  Gangadhar J. Sanjayan*a  

* Corresponding authors

a Division of Organic Synthesis, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India
E-mail: gj.sanjayan@ncl.res.in
Fax: +91 020-25902629
Tel: +91 020-25902629

b Central NMR Facility, National Chemical Laboratory, Pune, India

c Centre for Material Characterization, National Chemical Laboratory, Pune, India

Abstract

Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.

Graphical abstract: Multifaceted folding in a foldamer featuring highly cooperative folds

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC35649J
Article type
Communication
Submitted
03 Aug 2012
Accepted
25 Sep 2012
First published
26 Sep 2012

Chem. Commun., 2012,48, 11205-11207

Permissions

Request permissions

Multifaceted folding in a foldamer featuring highly cooperative folds

V. V. E. Ramesh, G. Priya, A. S. Kotmale, R. G. Gonnade, P. R. Rajamohanan and G. J. Sanjayan, Chem. Commun., 2012, 48, 11205 DOI: 10.1039/C2CC35649J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements