Issue 93, 2012

Palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides to give 4-amine-benzo[b][1,4]oxazepines

Abstract

A robust route to 4-amine-benzo[b][1,4]oxazepines relying upon a palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides has been developed. This chemistry presumably proceeds through the migratory insertion of isocyanides into the vinyl-palladium intermediate as a key step.

Graphical abstract: Palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides to give 4-amine-benzo[b][1,4]oxazepines

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2012
Accepted
06 Oct 2012
First published
08 Oct 2012

Chem. Commun., 2012,48, 11446-11448

Palladium-catalyzed tandem reaction of o-aminophenols, bromoalkynes and isocyanides to give 4-amine-benzo[b][1,4]oxazepines

B. Liu, Y. Li, M. Yin, W. Wu and H. Jiang, Chem. Commun., 2012, 48, 11446 DOI: 10.1039/C2CC35802F

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