Issue 91, 2012
From the journal:

Chemical Communications

Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines†

Xinxin Qi,a   Lu Daia  and  Cheol-Min Park*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
E-mail: cmpark@ntu.edu.sg
Fax: +65-6513-2748
Tel: +65-6513-2748

Abstract

Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N–O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh2(tfacam)4 rapidly provides a variety of pyridines in 5–10 minutes in good to excellent yields.

Graphical abstract: Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

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Article information

DOI
https://doi.org/10.1039/C2CC36009H
Article type
Communication
Submitted
18 Aug 2012
Accepted
25 Sep 2012
First published
26 Sep 2012

Chem. Commun., 2012,48, 11244-11246

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Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

X. Qi, L. Dai and C. Park, Chem. Commun., 2012, 48, 11244 DOI: 10.1039/C2CC36009H

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