Issue 92, 2012

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Abstract

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP5 binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

Graphical abstract: First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Supplementary files

Article information

Article type
Communication
Submitted
20 Aug 2012
Accepted
14 Sep 2012
First published
18 Sep 2012
This article is Open Access

Chem. Commun., 2012,48, 11292-11294

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

A. M. Riley, H. Wang, J. D. Weaver, S. B. Shears and B. V. L. Potter, Chem. Commun., 2012, 48, 11292 DOI: 10.1039/C2CC36044F

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