Issue 94, 2012
From the journal:

Chemical Communications

A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission†

Koushik Dhara,a   Yuichiro Hori,a   Reisuke Babaa  and  Kazuya Kikuchi*ab  

* Corresponding authors

a Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan
E-mail: kkikuchi@mls.eng.osaka-u.ac.jp
Web: http://www-molpro.mls.eng.osaka-u.ac.jp/
Fax: +81 6-6879-7875

b Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan

Abstract

A tetraphenylethylene-derivative fluorescent probe for the one-step detection of histone deacetylases (HDAC) was developed. The deacetylation of the probe triggers electrostatic interaction between the molecules and automatically leads to fluorescence enhancement based on aggregation-induced emission (AIE).

Graphical abstract: A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

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Article information

DOI
https://doi.org/10.1039/C2CC36591J
Article type
Communication
Submitted
11 Sep 2012
Accepted
11 Oct 2012
First published
23 Oct 2012

Chem. Commun., 2012,48, 11534-11536

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A fluorescent probe for detection of histone deacetylase activity based on aggregation-induced emission

K. Dhara, Y. Hori, R. Baba and K. Kikuchi, Chem. Commun., 2012, 48, 11534 DOI: 10.1039/C2CC36591J

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