Issue 97, 2012
From the journal:

Chemical Communications

Clicked europium dipicolinate complexes for protein X-ray structure determination†

Romain Talon,abc   Lionel Nauton,de   Jean-Louis Canet,d   Richard Kahn,abc   Eric Girard*abc  and  Arnaud Gautier*de  

* Corresponding authors

a CEA, DSV, Institut de Biologie Structurale (IBS), 41 rue Jules Horowitz, Grenoble F–38027, France

b CNRS, Grenoble, France

c Université Joseph Fourier, Grenoble 1, France
E-mail: eric.girard@ibs.fr
Fax: +33 (0)4 38 78 54 94
Tel: +33 (0)4 38 78 96 45

d Clermont Université, Université Blaise Pascal et ENSCCF, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand Aubière, France

e CNRS, UMR 6296, ICCF, F-63171 Aubière, France
E-mail: arnaud.gautier@univ-bpclermont.fr
Fax: +33 (0)4 73 40 77 17
Tel: +33 (0)4 73 40 76 46

Abstract

New trisdipicolinic acid–lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination.

Graphical abstract: Clicked europium dipicolinate complexes for protein X-ray structure determination

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Article information

DOI
https://doi.org/10.1039/C2CC36982F
Article type
Communication
Submitted
26 Sep 2012
Accepted
23 Oct 2012
First published
23 Oct 2012

Chem. Commun., 2012,48, 11886-11888

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Clicked europium dipicolinate complexes for protein X-ray structure determination

R. Talon, L. Nauton, J. Canet, R. Kahn, E. Girard and A. Gautier, Chem. Commun., 2012, 48, 11886 DOI: 10.1039/C2CC36982F

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