Issue 100, 2012
From the journal:

Chemical Communications

Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines†

Tian-Lin Liu,a   Heng-Xia Zhang,a   Yan Zheng,a   Qingwei Yaob  and  Jun-An Ma*a  

* Corresponding authors

a Department of Chemistry, Tianjin University, Tianjin 300072, China
E-mail: majun_an68@tju.edu.cn
Fax: +86-22-2740-3475

b Sphinx Scientific Laboratory Corporation, Sycamore, IL 60178, USA

Abstract

An efficient method for the asymmetric synthesis of chiral diynylated carbinamines is described. The direct catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines proceeded smoothly under mild reaction conditions to produce diynylated carbinamines in up to 98% yield and 99% ee.

Graphical abstract: Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines

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Article information

DOI
https://doi.org/10.1039/C2CC37290H
Article type
Communication
Submitted
06 Oct 2012
Accepted
30 Oct 2012
First published
30 Oct 2012

Chem. Commun., 2012,48, 12234-12236

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Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines

T. Liu, H. Zhang, Y. Zheng, Q. Yao and J. Ma, Chem. Commun., 2012, 48, 12234 DOI: 10.1039/C2CC37290H

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