Multiphase enantioselective Kharasch–Sosnovsky allylic oxidation based on neoteric solvents and copper complexes of ditopic ligands

Abstract

Recoverable multiphase enantioselective catalytic systems for the Kharasch–Sosnovsky oxidation of cycloalkenes with tert-butyl peroxybenzoate are described, based on the use of [BMIM][PF₆] and a new solvent derived from glycerol as the catalyst reservoir phases, and chiral copper complexes with different ligands from the bis(oxazoline) family. The best results are obtained with the glycerol-derived solvent and a recently described azabisoxazoline-based ditopic ligand, allowing up to four uses of the catalytic phase with good results.