Issue 18, 2012

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Abstract

Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM−1 s−1, 30 MHz, 25 °C) contrast agent potentially safe for in vivo MRI applications. The Lipari–Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.

Graphical abstract: Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2012
Accepted
13 Mar 2012
First published
13 Mar 2012

Dalton Trans., 2012,41, 5472-5475

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

M. F. Ferreira, B. Mousavi, P. M. Ferreira, C. I. O. Martins, L. Helm, J. A. Martins and C. F. G. C. Geraldes, Dalton Trans., 2012, 41, 5472 DOI: 10.1039/C2DT30388D

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