An 1,3,4-oxadiazole-based OFF–ON fluorescent chemosensor for Zn2+ in aqueous solution and imaging application in living cells

Ji-An Zhou; Xiao-Liang Tang; Ju Cheng; Zheng-Hua Ju; Li-Zi Yang; Wei-Sheng Liu; Chun-Yang Chen; De-Cheng Bai

doi:10.1039/C2DT30852E

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An 1,3,4-oxadiazole-based OFF–ON fluorescent chemosensor for Zn²⁺ in aqueous solution and imaging application in living cells†

Ji-An Zhou,^a Xiao-Liang Tang,^a Ju Cheng,^b Zheng-Hua Ju,^a Li-Zi Yang,^a Wei-Sheng Liu,*^a Chun-Yang Chen^a and De-Cheng Bai^b

Author affiliations

* Corresponding authors

^a Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China
E-mail: liuws@lzu.edu.cn
Fax: +86-931-8912582
Tel: +86-931-8915151

^b School of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China

Abstract

A new 1,3,4-oxadiazole-based fluorescence chemosensor 1, N-(2-ethoxy-2-oxoethyl)-N-(5-(2-hydroxy-3,5-di-tert-butylphenyl)-[1,3,4]oxadiazol-2-yl)glycine ethyl ester, has been designed and synthesized. Its fluorescence properties and selectivity for various metal ions were investigated in detail. A prominent fluorescence enhancement only for Zn²⁺ was found in aqueous acetonitrile solution and the response mechanism of 1 was analyzed by time-resolved fluorescence decay and DFT calculations. Furthermore, the fluorescence imaging of Zn²⁺ in living cells was successfully applied.

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Article information

DOI: https://doi.org/10.1039/C2DT30852E
Article type: Paper
Submitted: 18 Apr 2012
Accepted: 27 Jun 2012
First published: 28 Jun 2012

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Dalton Trans., 2012,41, 10626-10632

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An 1,3,4-oxadiazole-based OFF–ON fluorescent chemosensor for Zn²⁺ in aqueous solution and imaging application in living cells

J. Zhou, X. Tang, J. Cheng, Z. Ju, L. Yang, W. Liu, C. Chen and D. Bai, Dalton Trans., 2012, 41, 10626 DOI: 10.1039/C2DT30852E

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