Issue 11, 2012
From the journal:

Green Chemistry

Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents†‡

Donna S. MacMillan,a   Jane Murray,b   Helen F. Sneddon,c   Craig Jamiesona  and  Allan J. B. Watson*a  

* Corresponding authors

a Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, UK
E-mail: allan.watson.100@strath.ac.uk
Fax: +44 (0)141 548 4822
Tel: +44 (0)141 548 2439

b Sigma-Aldrich, The Old Brickyard, New Road, Gillingham, Dorset, UK

c Green Chemistry Performance Unit, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK

Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

Graphical abstract: Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

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Article information

DOI
https://doi.org/10.1039/C2GC36378J
Article type
Communication
Submitted
30 Aug 2012
Accepted
28 Sep 2012
First published
02 Oct 2012

Green Chem., 2012,14, 3016-3019

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Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Green Chem., 2012, 14, 3016 DOI: 10.1039/C2GC36378J

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