In situ mechanical analysis of cardiomyocytes at nano scales

Yuansheng Liu; Jiantao Feng; Liang Shi; Ruibin Niu; Quanmei Sun; Hao Liu; Jing Li; Jihong Guo; Jihong Zhu; Dong Han

doi:10.1039/C1NR11303H

In situ mechanical analysis of cardiomyocytes at nano scales

Yuansheng Liu,†^ab Jiantao Feng,†^b Liang Shi,^c Ruibin Niu,^d Quanmei Sun,^b Hao Liu,^e Jing Li,^b Jihong Guo,^a Jihong Zhu^a and Dong Han*^b

Author affiliations

* Corresponding authors

^a Emergency Department, Peking University People's Hospital, Beijing, People's Republic of China

^b National Center for Nanoscience and Technology, Beijing, People's Republic of China
E-mail: dhan@nanoctr.cn
Fax: +86 010 62656765
Tel: +86 010 82545568

^c Department of Stomatoiogy, 306 Hospital, Beijing, People's Republic of China

^d Clinical Laboratory, Ordos Central Hospital, Ordos, People's Republic of China

^e Intensive Care Unit, the First People's Hospital of Hangzhou City, Hangzhou, People's Republic of China

Abstract

Nanomechanical behaviors of single living cardiomyocytes are quantitatively observed using calculated torsions and deflections of an AFM cantilever. The lateral contractions are related to the calcium intensity within rather than the vertical beating power of the cardiomyocytes. Drug-induced nanomechanical changes of cardiomyocytes were further investigated by measuring lateral contractions in real time.

Nanoscale

In situ mechanical analysis of cardiomyocytes at nano scales

Abstract

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In situ mechanical analysis of cardiomyocytes at nano scales

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