Issue 4, 2012
From the journal:

Organic & Biomolecular Chemistry

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues†

Olaia Nieto-García,a   Hugo Lago-Santomé,a   Fernando Cagide-Fagín,b   Juan Carlos Ortiz-Larac  and  Ricardo Alonso*a  

* Corresponding authors

a Departamento de Química Orgánica, Universidad de Santiago, Santiago de Compostela, Spain
E-mail: r.alonso@usc.es
Fax: +34 981 595012
Tel: +34 981 563100 Ext 14250

b Currently at the University of Porto: CIQ/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal

c Currently at Sintenovo S.A. de C.V.: Calle 4, no. 26, Naucalpan de Juárez, Estado de México, México
Fax: 0052 55761358
Tel: 0052 55760396

Abstract

A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.

Graphical abstract: A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

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Article information

DOI
https://doi.org/10.1039/C1OB06374J
Article type
Paper
Submitted
12 Aug 2011
Accepted
04 Oct 2011
First published
14 Oct 2011

Org. Biomol. Chem., 2012,10, 825-834

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A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

O. Nieto-García, H. Lago-Santomé, F. Cagide-Fagín, J. C. Ortiz-Lara and R. Alonso, Org. Biomol. Chem., 2012, 10, 825 DOI: 10.1039/C1OB06374J

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