Issue 3, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of manzacidin A and C: efficient construction of quaternary carbon stereocenters bearing nitrogen substituents†

Yoshiyasu Ichikawa,*a   Ken Okumura,a   Yasunori Matsuda,a   Tomoyuki Hasegawa,a   Mitsuhiro Nakamura,b   Aya Fujimoto,b   Toshiya Masuda,b   Keiji Nakanoa  and  Hiyoshizo Kotsukia  

* Corresponding authors

a Faculty of Science, Kochi University, Akebono-cho, Japan
E-mail: ichikawa@kochi-u.ac.jp

b Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770-8502, Japan

Abstract

An efficient synthetic method for stereoselective construction of asymmetric quaternary carbon stereocenters, bearing nitrogen in the form of Boc-protected allyl amines, has been developed. This methodology is employed in the synthesis of marine alkaloids, manzacidin A and C.

Graphical abstract: Synthesis of manzacidin A and C: efficient construction of quaternary carbon stereocenters bearing nitrogen substituents

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Article information

DOI
https://doi.org/10.1039/C1OB06559A
Article type
Paper
Submitted
12 Sep 2011
Accepted
05 Oct 2011
First published
05 Oct 2011

Org. Biomol. Chem., 2012,10, 614-622

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Synthesis of manzacidin A and C: efficient construction of quaternary carbon stereocenters bearing nitrogen substituents

Y. Ichikawa, K. Okumura, Y. Matsuda, T. Hasegawa, M. Nakamura, A. Fujimoto, T. Masuda, K. Nakano and H. Kotsuki, Org. Biomol. Chem., 2012, 10, 614 DOI: 10.1039/C1OB06559A

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