Issue 2, 2012

Design, synthesis, and application of tartaric acid derived N-spiroquaternary ammonium salts as chiral phase-transfer catalysts

Abstract

A novel class of tartaric acid-derived N-spiro quaternary ammonium salts was synthesised starting from known TADDOLs. These compounds were found to catalyse the asymmetric α-alkylation of glycine Schiff bases with high enantioselectivities and in good yields.

Graphical abstract: Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts

Supplementary files

Article information

Article type
Communication
Submitted
14 Sep 2011
Accepted
14 Oct 2011
First published
17 Oct 2011
This article is Open Access

Org. Biomol. Chem., 2012,10, 251-254

Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts

M. Waser, K. Gratzer, R. Herchl and N. Müller, Org. Biomol. Chem., 2012, 10, 251 DOI: 10.1039/C1OB06573D

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