Issue 11, 2012

Copper(i)–amine metallo-organocatalyzed synthesis of carbo- and heterocyclic systems

Abstract

The efficient and atom economical synthesis of 5-membered cyclic structures has been achieved through the combination of amino catalysis and metal catalysis. The discovery of a novel metallo-organocatalytic system merging the use of a catalytic copper(I) complex and a catalytic amount of cyclohexylamine allowed the room temperature preparation of a broad range of skeletons such as cyclopentanes, indanes, pyrrolidines and tetrahydrofuran, important structural cores of many biologically relevant molecules. Mechanistic studies were presented.

Graphical abstract: Copper(i)–amine metallo-organocatalyzed synthesis of carbo- and heterocyclic systems

Supplementary files

Article information

Article type
Paper
Submitted
24 Aug 2011
Accepted
21 Dec 2011
First published
22 Dec 2011

Org. Biomol. Chem., 2012,10, 2300-2306

Copper(I)–amine metallo-organocatalyzed synthesis of carbo- and heterocyclic systems

B. Montaignac, V. Östlund, M. R. Vitale, V. Ratovelomanana-Vidal and V. Michelet, Org. Biomol. Chem., 2012, 10, 2300 DOI: 10.1039/C2OB06449A

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