Issue 9, 2012
From the journal:

Organic & Biomolecular Chemistry

Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening†

Eleni Kyriakou,a   Alexandra Primikyri,a   Pantelis Charisiadis,a   Maria Katsoura,b   Ioannis P. Gerothanassis,a   Haralambos Stamatisb  and  Andreas G. Tzakos*a  

* Corresponding authors

a Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina GR-45110, Greece
E-mail: atzakos@cc.uoi.gr
Tel: (+30)2651-00-8387

b Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, Greece

Abstract

Unprecedented regioselective acylation of flavonoid aglycones was achieved using Candida antarcticalipase B (CALB). The rapid screening of product formation was performed by the use of the high resolution phenol-type OH 1H NMR spectral region recorded after the addition of picric acid.

Graphical abstract: Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening

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Article information

DOI
https://doi.org/10.1039/C2OB06784F
Article type
Communication
Submitted
23 Oct 2011
Accepted
14 Dec 2011
First published
19 Dec 2011

Org. Biomol. Chem., 2012,10, 1739-1742

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Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening

E. Kyriakou, A. Primikyri, P. Charisiadis, M. Katsoura, I. P. Gerothanassis, H. Stamatis and A. G. Tzakos, Org. Biomol. Chem., 2012, 10, 1739 DOI: 10.1039/C2OB06784F

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