Issue 25, 2012

Traceless chemical ligations from O-acyl serine sites

Abstract

Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.

Graphical abstract: Traceless chemical ligations from O-acyl serine sites

Supplementary files

Article information

Article type
Communication
Submitted
07 Dec 2011
Accepted
11 Apr 2012
First published
16 Apr 2012

Org. Biomol. Chem., 2012,10, 4836-4838

Traceless chemical ligations from O-acyl serine sites

M. El Khatib, M. Elagawany, F. Jabeen, E. Todadze, O. Bol'shakov, A. Oliferenko, L. Khelashvili, S. A. El-Feky, A. Asiri and A. R. Katritzky, Org. Biomol. Chem., 2012, 10, 4836 DOI: 10.1039/C2OB07050B

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