Issue 11, 2012
From the journal:

Organic & Biomolecular Chemistry

Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams†‡

Feng Pan,a   Jian-Ming Chen,a   Zhe Zhuang,a   Yin-Zhi Fang,a   Sean Xiao-An Zhanga  and  Wei-Wei Liao*a  

* Corresponding authors

a Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China
E-mail: wliao@jlu.edu.cn
Tel: (+86) 0431-85168420

Abstract

The first tertiary amine-catalyzed multicomponent tandem Strecker–allylic-alkylation (SAA) reaction has been developed, which provides a facile access to functionalized α-amino nitriles, which could be readily converted into α-methylene-γ-butyrolactams.

Graphical abstract: Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB07112F
Article type
Communication
Submitted
16 Dec 2011
Accepted
17 Jan 2012
First published
10 Feb 2012

Org. Biomol. Chem., 2012,10, 2214-2217

Permissions

Request permissions

Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams

F. Pan, J. Chen, Z. Zhuang, Y. Fang, S. X. Zhang and W. Liao, Org. Biomol. Chem., 2012, 10, 2214 DOI: 10.1039/C2OB07112F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements