Issue 23, 2012

A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

Abstract

We present here a new, general, solid phase strategy for the synthesis of sequence independent peptidyl-fluoromethyl ketones using standard Fmoc peptide chemistry. Our method is based on the synthesis of bifunctional linkers which allows the incorporation of amino acid fluoromethyl ketone unit at the C-terminal end of peptide sequences. Application of this approach for the synthesis of activity based probes for SENPs is also described.

Graphical abstract: A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

Supplementary files

Article information

Article type
Paper
Submitted
13 Jan 2012
Accepted
03 Apr 2012
First published
03 Apr 2012

Org. Biomol. Chem., 2012,10, 4516-4523

A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

G. Roiban, M. Matache, N. D. Hădade and D. P. Funeriu, Org. Biomol. Chem., 2012, 10, 4516 DOI: 10.1039/C2OB25096A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements