Issue 27, 2012
From the journal:

Organic & Biomolecular Chemistry

Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction†

Wen-Tao Wei,a   Chun-Xia Chen,a   Rui-Jiong Lu,a   Jin-Jia Wang,a   Xue-Jing Zhanga  and  Ming Yan*a  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: yanming@mail.sysu.edu.cn
Fax: +86-20-39943049

Abstract

An organocatalytic three-component reaction of isatins, malononitrile and isocyanoacetates provided 3,3′-dihydropyrryl-spirooxindoles in excellent yields and enantioselectivities. The products could be readily converted to valuable 3,3′-pyrrolidinyl-spirooxindoles.

Graphical abstract: Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25629K
Article type
Paper
Submitted
27 Mar 2012
Accepted
17 May 2012
First published
11 Jun 2012

Org. Biomol. Chem., 2012,10, 5245-5252

Permissions

Request permissions

Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

W. Wei, C. Chen, R. Lu, J. Wang, X. Zhang and M. Yan, Org. Biomol. Chem., 2012, 10, 5245 DOI: 10.1039/C2OB25629K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements