Issue 26, 2012
From the journal:

Organic & Biomolecular Chemistry

A multicomponent synthetic strategy for two-carbon-tethered 1,3-oxathiole–indole pairs†

Jia-Yan Liu,a   Hao Zhang,a   Bao-Ming Feng,a   Bo Jiang,*a   Shu-Liang Wanga  and  Shu-Jiang Tu*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, P.R. China
E-mail: jiangchem@xznu.edu.cn, laotu@xznu.edu.cn
Fax: +86-516-83500065
Tel: +86-516-83500065

Abstract

An efficient methodology for the multicomponent synthesis of new and highly functionalized heterocycles containing 1,3-oxathiole and indole units which are connected through an sp2-C2 bridge has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C–S bond and a C–O bond in a one-pot operation. Features of this strategy include mild conditions, convenient one-pot operation, and high stereo- and regioselectivity.

Graphical abstract: A multicomponent synthetic strategy for two-carbon-tethered 1,3-oxathiole–indole pairs

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Article information

DOI
https://doi.org/10.1039/C2OB25817J
Article type
Communication
Submitted
28 Apr 2012
Accepted
23 May 2012
First published
25 May 2012

Org. Biomol. Chem., 2012,10, 5036-5038

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A multicomponent synthetic strategy for two-carbon-tethered 1,3-oxathiole–indole pairs

J. Liu, H. Zhang, B. Feng, B. Jiang, S. Wang and S. Tu, Org. Biomol. Chem., 2012, 10, 5036 DOI: 10.1039/C2OB25817J

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