Issue 32, 2012
From the journal:

Organic & Biomolecular Chemistry

A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines†

Ke Chena  and  Sumod A. Pullarkat*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: sumod@ntu.edu.sg
Tel: +65-63168906

Abstract

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.

Graphical abstract: A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

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Article information

DOI
https://doi.org/10.1039/C2OB25854D
Article type
Paper
Submitted
04 May 2012
Accepted
21 Jun 2012
First published
21 Jun 2012

Org. Biomol. Chem., 2012,10, 6600-6606

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A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

K. Chen and S. A. Pullarkat, Org. Biomol. Chem., 2012, 10, 6600 DOI: 10.1039/C2OB25854D

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