Issue 34, 2012
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates†

Kalicharan Cattopadhyay,a   Antonio Recio IIIb  and  Jon A. Tunge*b  

* Corresponding authors

a Haldia Institute of Technology, West Bengal, India
E-mail: chatterjee_k80@yahoo.co.in

b 2010 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, USA
E-mail: tunge@ku.edu
Fax: +1 (785) 864 5396
Tel: +1 (785) 864-4136

Abstract

We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd–π-benzyl complex generated from (coumarinyl)methyl acetates.

Graphical abstract: Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

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Article information

DOI
https://doi.org/10.1039/C2OB25962A
Article type
Communication
Submitted
18 May 2012
Accepted
06 Jul 2012
First published
12 Jul 2012

Org. Biomol. Chem., 2012,10, 6826-6829

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Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

K. Cattopadhyay, A. Recio III and J. A. Tunge, Org. Biomol. Chem., 2012, 10, 6826 DOI: 10.1039/C2OB25962A

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