Issue 34, 2012
From the journal:

Organic & Biomolecular Chemistry

A NIR BODIPY dye bearing 3,4,4a-trihydroxanthene moieties†

Xin-Dong Jiang,*a   Ruina Gao,a   Yi Yue,a   Guo-Tao Sunb  and  Weili Zhao*ac  

* Corresponding authors

a The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng, Henan 475004, China
E-mail: xdjiang@henu.edu.cn, zhaow@henu.edu.cn
Tel: +86 0378 3881358

b Department of Biochemistry and Molecular Biology, Institute of Molecular Medicine, Medical School, Henan University, Kaifeng, Henan 475004, China

c School of Pharmacy, Fudan University, Shanghai, China

Abstract

A novel 3,4,4a-trihydroxanthene-fused pyrrole 2 was synthesized by the reaction of 2,3,4,4a-tetrahydro-1H-xanthen-1-one with 3-phenyl-2H-azirine in the presence of LDA. Utilizing this pyrrole 2, a NIR BODIPY 1 (λabs = 732 nm, λem = 747 nm) has been prepared. The new BODIPY 1 was stable, non-cytotoxic, and suited to labeling living cells for imaging assay in the NIR region.

Graphical abstract: A NIR BODIPY dye bearing 3,4,4a-trihydroxanthene moieties

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Article information

DOI
https://doi.org/10.1039/C2OB26218E
Article type
Paper
Submitted
14 May 2012
Accepted
06 Jul 2012
First published
06 Jul 2012

Org. Biomol. Chem., 2012,10, 6861-6865

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A NIR BODIPY dye bearing 3,4,4a-trihydroxanthene moieties

X. Jiang, R. Gao, Y. Yue, G. Sun and W. Zhao, Org. Biomol. Chem., 2012, 10, 6861 DOI: 10.1039/C2OB26218E

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