Issue 46, 2012
From the journal:

Organic & Biomolecular Chemistry

An efficient and novel approach for the synthesis of substituted N-aryl lactams

Devdutt Chaturvedi,*a   Amit K. Chaturvedi,b   Nisha Mishrab  and  Virendra Mishrab  

* Corresponding authors

a Laboratory of Medicinal Chemistry, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow-226010, U. P., India
E-mail: devduttchaturvedi@gmail.com, dchaturvedi@lko.amity.edu

b Synthetic Research Laboratory, Department of Chemistry, B. S. A. P. G. College, Mathura-281004, U. P., India

Abstract

A quick, efficient, one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acid chlorides using a Lewis acid (i.e. EtAlCl2) at room temperature, through the in situ involvement of a Friedel–Crafts reaction followed by intramolecular Schimdt rearrangement was developed, and afforded good to excellent yields.

Graphical abstract: An efficient and novel approach for the synthesis of substituted N-aryl lactams

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Article information

DOI
https://doi.org/10.1039/C2OB26230D
Article type
Communication
Submitted
28 Jun 2012
Accepted
16 Oct 2012
First published
16 Oct 2012

Org. Biomol. Chem., 2012,10, 9148-9151

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An efficient and novel approach for the synthesis of substituted N-aryl lactams

D. Chaturvedi, A. K. Chaturvedi, N. Mishra and V. Mishra, Org. Biomol. Chem., 2012, 10, 9148 DOI: 10.1039/C2OB26230D

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